A curated review of the scientific literature on eosinophilic fasciitis — from Shulman's 1974 description to the latest clinical reports.
10Entries
1974 — 2024Time span
0Randomised trials
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/ 01
Cornerstone publications
1975Original description
Diffuse fasciitis with eosinophilia: a new syndrome?
Shulman LE
Trans Assoc Am Physicians · 88:70-86
Key takeaway
First description of a new syndrome — diffuse fasciitis with eosinophilia, distinguished from scleroderma by the sparing of the fingers, the absence of Raynaud's phenomenon and the dramatic response to corticosteroids.
Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases
Lakhanpal S, Ginsburg WW, Michet CJ, Doyle JA, Moore SB
Semin Arthritis Rheum · 17(4):221-231
Key takeaway
First large single-centre cohort (Mayo Clinic): 52 patients, the modern phenotype of EF — frequent flexion contractures (n = 29), associated morphea (n = 15), carpal tunnel syndrome (n = 12) and a handful of haematological associations.
Moulton SJ, Kransdorf MJ, Ginsburg WW, Abril A, Persellin S
AJR Am J Roentgenol · 184(3):975-978
Key takeaway
Reference MRI series: fascial T2 hyperintensity and post-gadolinium enhancement are characteristic findings and correlate with disease activity, supporting MRI as a non-invasive tool for both diagnosis and monitoring.
The benchmark clinical review of the past 15 years — a synthesis of clinical presentation, the diagnostic workup and therapeutic options for what was still called Shulman disease at that time.
Diagnosis and classification of eosinophilic fasciitis
Pinal-Fernandez I, Selva-O'Callaghan A, Grau JM
Autoimmun Rev · 13(4-5):379-382
Key takeaway
First formal set of diagnostic criteria for EF: one major criterion (skin/subcutaneous induration sparing the digits) plus minor criteria covering eosinophilia, hypergammaglobulinaemia, MRI and histology. Still the most cited framework.
Baseline characteristics and long-term outcomes of eosinophilic fasciitis in 89 patients seen at a single center over 20 years
Mango RL, Bugdayli K, Crowson CS, et al.
Int J Rheum Dis · 23(2):233-239
Key takeaway
Largest long-term cohort to date: 89 Mayo Clinic patients followed over 20 years. Most cases are self-limited once treated; combined corticosteroids and methotrexate produce the best outcomes, with disability concentrated in patients with a delayed start of therapy.
Epidemiology and treatment of eosinophilic fasciitis: an analysis of 63 patients from 3 tertiary care centers
Wright NA, Mazori DR, Patel M, Merola JF, Femia AN, Vleugels RA
JAMA Dermatol · 152(1):97-99
Key takeaway
Three-centre cohort, n = 63: complete remission reached 64 % under prednisone + methotrexate versus 30 % under prednisone alone, establishing combination therapy as the de-facto first line.
Eosinophilic fasciitis: an updated review on diagnosis and treatment
Mazori DR, Femia AN, Vleugels RA
Curr Rheumatol Rep · 19(12):74
Key takeaway
Updated practical review — diagnostic pitfalls, a treatment algorithm and a re-evaluation of biologics (rituximab, tocilizumab) for refractory disease.
Clinical guide to eosinophilic fasciitis: straddling dermatology and rheumatology
Onajin O, Wieland CN, Peters MS, Lehman JS, Gibson LE
Expert Rev Clin Immunol · 18(7):707-718
Key takeaway
Joint dermatology–rheumatology guide: the practical handbook for the clinician seeing the patient for the first time, with photo-illustrated criteria and a graded decision algorithm.
Eosinophilic fasciitis following COVID-19: a case series of 3 patients
Li Y, Kong HE, Cheeley J
JAAD Case Rep · 44:6-10
Key takeaway
Three patients developing EF after a SARS-CoV-2 infection — the first published series supporting a viral trigger for the disease in part of the population.